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Substance dependence

MedGen UID:
20989
•Concept ID:
C0038580
•
Mental or Behavioral Dysfunction
Synonyms: Addiction, Substance; Chemical Dependence; Chemical Dependences; Dependence, Chemical; Dependence, Substance; Dependences, Chemical; Substance Addiction; Substance Dependence
SNOMED CT: Substance dependence (1254812006)
 
Monarch Initiative: MONDO:0004938

Definition

The psychological or physiological need to take a substance in order to experience its effects or to avoid the effects of its absence. [from MONDO]

Professional guidelines

PubMed

Treatment resistance in psychiatry: state of the art and new directions.
Howes OD, Thase ME, Pillinger T
Mol Psychiatry 2022 Jan;27(1):58-72. Epub 2021 Jul 13 doi: 10.1038/s41380-021-01200-3. PMID: 34257409Free PMC Article
Psychosocial impact of COVID-19.
Dubey S, Biswas P, Ghosh R, Chatterjee S, Dubey MJ, Chatterjee S, Lahiri D, Lavie CJ
Diabetes Metab Syndr 2020 Sep-Oct;14(5):779-788. Epub 2020 May 27 doi: 10.1016/j.dsx.2020.05.035. PMID: 32526627Free PMC Article
Is deep brain stimulation a treatment option for addiction?
Luigjes J, van den Brink W, Schuurman PR, Kuhn J, Denys D
Addiction 2015 Apr;110(4):547-8. doi: 10.1111/add.12773. PMID: 25771687

Recent clinical studies

Etiology

Gender differences in the young-onset persistent delusional disorder.
Arasappa R, Chithra NK, Kulkarni KR, Muliyala KP, Murthy P, Kesavan M
Asian J Psychiatr 2023 Aug;86:103653. Epub 2023 May 24 doi: 10.1016/j.ajp.2023.103653. PMID: 37270876
Executive function in methamphetamine users with and without psychosis.
Koopowitz SM, Cotton SM, Uhlmann A, Thomas KGF, Stein DJ
Psychiatry Res 2022 Nov;317:114820. Epub 2022 Aug 31 doi: 10.1016/j.psychres.2022.114820. PMID: 36075151
Family-Based Treatments for Adolescent Substance Use.
Horigian VE, Anderson AR, Szapocznik J
Child Adolesc Psychiatr Clin N Am 2016 Oct;25(4):603-28. Epub 2016 Aug 3 doi: 10.1016/j.chc.2016.06.001. PMID: 27613341Free PMC Article
Preoperative Assessment of Geriatric Patients.
Nakhaie M, Tsai A
Anesthesiol Clin 2015 Sep;33(3):471-80. Epub 2015 Jul 7 doi: 10.1016/j.anclin.2015.05.005. PMID: 26315632
Chronic pain and addiction: challenging co-occurring disorders.
Pohl M, Smith L
J Psychoactive Drugs 2012 Apr-Jun;44(2):119-24. doi: 10.1080/02791072.2012.684621. PMID: 22880539

Diagnosis

Reward Prediction Errors in Drug Addiction and Parkinson's Disease: from Neurophysiology to Neuroimaging.
García-García I, Zeighami Y, Dagher A
Curr Neurol Neurosci Rep 2017 Jun;17(6):46. doi: 10.1007/s11910-017-0755-9. PMID: 28417291
Influence of the Novelty-Seeking Endophenotype on the Rewarding Effects of Psychostimulant Drugs in Animal Models.
Arenas MC, Aguilar MA, Montagud-Romero S, Mateos-García A, Navarro-Francés CI, Miñarro J, Rodríguez-Arias M
Curr Neuropharmacol 2016;14(1):87-100. doi: 10.2174/1570159x13666150921112841. PMID: 26391743Free PMC Article
Diagnosis and consequences of cocaine addiction.
Karila L, Petit A, Lowenstein W, Reynaud M
Curr Med Chem 2012;19(33):5612-8. doi: 10.2174/092986712803988839. PMID: 22856661
Neurocognitive endophenotypes of impulsivity and compulsivity: towards dimensional psychiatry.
Robbins TW, Gillan CM, Smith DG, de Wit S, Ersche KD
Trends Cogn Sci 2012 Jan;16(1):81-91. Epub 2011 Dec 10 doi: 10.1016/j.tics.2011.11.009. PMID: 22155014
Addiction medicine.
Franklin JE
JAMA 1995 Jun 7;273(21):1656-7. PMID: 7752401

Therapy

DARK Classics in Chemical Neuroscience: Loperamide.
Malinky CA, Lindsley CW, Han C
ACS Chem Neurosci 2021 Aug 18;12(16):2964-2973. Epub 2021 Aug 4 doi: 10.1021/acschemneuro.1c00382. PMID: 34346690
Adult attention deficit/hyperactivity disorder in the ambulatory care setting.
Hackett A, Joseph R, Robinson K, Welsh J, Nicholas J, Schmidt E
JAAPA 2020 Aug;33(8):12-16. doi: 10.1097/01.JAA.0000684108.89007.52. PMID: 32740107
Ibogaine in the treatment of substance dependence.
Brown TK
Curr Drug Abuse Rev 2013 Mar;6(1):3-16. doi: 10.2174/15672050113109990001. PMID: 23627782
Just call it "treatment".
Friedmann PD, Schwartz RP
Addict Sci Clin Pract 2012 Jun 9;7(1):10. doi: 10.1186/1940-0640-7-10. PMID: 23186149Free PMC Article
The addiction potential of hyperpalatable foods.
Gearhardt AN, Davis C, Kuschner R, Brownell KD
Curr Drug Abuse Rev 2011 Sep;4(3):140-5. doi: 10.2174/1874473711104030140. PMID: 21999688

Prognosis

Global statistics on alcohol, tobacco and illicit drug use: 2017 status report.
Peacock A, Leung J, Larney S, Colledge S, Hickman M, Rehm J, Giovino GA, West R, Hall W, Griffiths P, Ali R, Gowing L, Marsden J, Ferrari AJ, Grebely J, Farrell M, Degenhardt L
Addiction 2018 Oct;113(10):1905-1926. Epub 2018 Jun 4 doi: 10.1111/add.14234. PMID: 29749059
Reward Prediction Errors in Drug Addiction and Parkinson's Disease: from Neurophysiology to Neuroimaging.
García-García I, Zeighami Y, Dagher A
Curr Neurol Neurosci Rep 2017 Jun;17(6):46. doi: 10.1007/s11910-017-0755-9. PMID: 28417291
Influence of the Novelty-Seeking Endophenotype on the Rewarding Effects of Psychostimulant Drugs in Animal Models.
Arenas MC, Aguilar MA, Montagud-Romero S, Mateos-García A, Navarro-Francés CI, Miñarro J, Rodríguez-Arias M
Curr Neuropharmacol 2016;14(1):87-100. doi: 10.2174/1570159x13666150921112841. PMID: 26391743Free PMC Article
Dialectical behavior therapy for personality disorders.
Rizvi SL, Linehan MM
Curr Psychiatry Rep 2001 Feb;3(1):64-9. doi: 10.1007/s11920-001-0075-1. PMID: 11177762
Inpatient vs outpatient treatment for substance dependence revisited.
Pettinati HM, Meyers K, Jensen JM, Kaplan F, Evans BD
Psychiatr Q 1993 Summer;64(2):173-82. doi: 10.1007/BF01065868. PMID: 8391147

Clinical prediction guides

A genome-wide association study of total child psychiatric problems scores.
Neumann A, Nolte IM, Pappa I, Ahluwalia TS, Pettersson E, Rodriguez A, Whitehouse A, van Beijsterveldt CEM, Benyamin B, Hammerschlag AR, Helmer Q, Karhunen V, Krapohl E, Lu Y, van der Most PJ, Palviainen T, St Pourcain B, Seppälä I, Suarez A, Vilor-Tejedor N, Tiesler CMT, Wang C, Wills A, Zhou A, Alemany S, Bisgaard H, Bønnelykke K, Davies GE, Hakulinen C, Henders AK, Hyppönen E, Stokholm J, Bartels M, Hottenga JJ, Heinrich J, Hewitt J, Keltikangas-Järvinen L, Korhonen T, Kaprio J, Lahti J, Lahti-Pulkkinen M, Lehtimäki T, Middeldorp CM, Najman JM, Pennell C, Power C, Oldehinkel AJ, Plomin R, Räikkönen K, Raitakari OT, Rimfeld K, Sass L, Snieder H, Standl M, Sunyer J, Williams GM, Bakermans-Kranenburg MJ, Boomsma DI, van IJzendoorn MH, Hartman CA, Tiemeier H
PLoS One 2022;17(8):e0273116. Epub 2022 Aug 22 doi: 10.1371/journal.pone.0273116. PMID: 35994476Free PMC Article
Influence of the Novelty-Seeking Endophenotype on the Rewarding Effects of Psychostimulant Drugs in Animal Models.
Arenas MC, Aguilar MA, Montagud-Romero S, Mateos-García A, Navarro-Francés CI, Miñarro J, Rodríguez-Arias M
Curr Neuropharmacol 2016;14(1):87-100. doi: 10.2174/1570159x13666150921112841. PMID: 26391743Free PMC Article
Dissecting ancestry genomic background in substance dependence genome-wide association studies.
Polimanti R, Yang C, Zhao H, Gelernter J
Pharmacogenomics 2015;16(13):1487-98. Epub 2015 Aug 12 doi: 10.2217/pgs.15.91. PMID: 26267224Free PMC Article
Gambling and problem gambling in The Netherlands.
Goudriaan AE
Addiction 2014 Jul;109(7):1066-71. Epub 2013 Jun 6 doi: 10.1111/add.12213. PMID: 23742239
Inpatient vs outpatient treatment for substance dependence revisited.
Pettinati HM, Meyers K, Jensen JM, Kaplan F, Evans BD
Psychiatr Q 1993 Summer;64(2):173-82. doi: 10.1007/BF01065868. PMID: 8391147

Recent systematic reviews

The Tolerability and Safety of Psilocybin in Psychiatric and Substance-Dependence Conditions: A Systematic Review.
Kaminski D, Reinert JP
Ann Pharmacother 2024 Aug;58(8):811-826. Epub 2023 Oct 30 doi: 10.1177/10600280231205645. PMID: 37902038
Mental Health Symptoms Associated with Sexualized Drug Use (Chemsex) among Men Who Have Sex with Men: A Systematic Review.
Íncera-Fernández D, Gámez-Guadix M, Moreno-Guillén S
Int J Environ Res Public Health 2021 Dec 17;18(24) doi: 10.3390/ijerph182413299. PMID: 34948907Free PMC Article
Nature of glutamate alterations in substance dependence: A systematic review and meta-analysis of proton magnetic resonance spectroscopy studies.
Chen T, Tan H, Lei H, Li X, Wu Q, Xu X, Ye Y, Zhong N, Du J, Jiang H, Su H, Zhao M
Psychiatry Res Neuroimaging 2021 Sep 30;315:111329. Epub 2021 Jul 7 doi: 10.1016/j.pscychresns.2021.111329. PMID: 34271295
Substance Use and Recidivism Outcomes for Prison-Based Drug and Alcohol Interventions.
de Andrade D, Ritchie J, Rowlands M, Mann E, Hides L
Epidemiol Rev 2018 Jun 1;40(1):121-133. doi: 10.1093/epirev/mxy004. PMID: 29733373
A Systematic Review of Dropout From Psychotherapy for Posttraumatic Stress Disorder Among Iraq and Afghanistan Combat Veterans.
Goetter EM, Bui E, Ojserkis RA, Zakarian RJ, Brendel RW, Simon NM
J Trauma Stress 2015 Oct;28(5):401-9. Epub 2015 Sep 16 doi: 10.1002/jts.22038. PMID: 26375387

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